Fabrication Lab Dispositif: A new model for a specialist lab and centre for knowledge generation and exchange

This is a major, institutionally-based research project investigating new models for testing, developing and disseminating ways of using the Fabrication Lab as an innovative platform for the generation and exchange of knowledge. The research project offers responses to the opportunities and threats posed by the rapidly advancing, potentially disruptive digital ecosystem of design and construction technologies taking hold of professional and industry practice. The project includes the innovative architecture, technology, structures and systems designed by the authors for the Lab, as well as the novel pedagogical, research and institutional practices and projects created using the Lab as a platform. Its principle working tool, as well as its largest output, is the Fabrication Lab itself, understood through the thought of Foucault as a dispositif, or ‘apparatus’. The research is based on an understanding of a lab that looks beyond its role as an institutional facility to focus on the multiple, heterogeneous elements through which the Lab, its staff, users, and technologies are constructed. The Fabrication Lab thus becomes an experimental vehicle to investigate how the system of relations between diverse institutional elements and situated practices might be re-thought and re- configured to generate the new technological objects, subjectivities, practices and pedagogic and research outputs required to keep pace with today’s rapidly advancing developments. As well as the Fabrication Lab itself, the research has produced many other outputs documented in the folio including: FAB FEST, a series of three major international fabrication and dissemination events attended by academics and practitioners from around the world; live projects in London, Helsinki and South Korea; numerous workshops, outreach projects and public events; academic conference papers and new knowledge exchange partnerships; as well as the thousands of experimental outputs produced in the Lab by academic staff, students and researchers at the University of Westminster

FAB FEST – International Fabrication Festival

FAB FEST is an International Fabrication Festival held at the University of Westminster in Central London. The festival is a unique pedagogic and social project, combining creative architectural design with innovative digital fabrication methods using lightweight, recyclable materials. It was introduced in 2016 and developed and repeated in the Summer of 2017. The festivals involved 50 teams of five or more students from across the UK and around the world including participants from India, China, USA, Turkey, Greece, Spain and Italy. Teams worked together over a four-month period to develop a design for a habitable pavilion. Groups combined students, professionals in practice acting as design mentors, as well as staff from the University’s Fabrication Lab, advising on materials and digital fabrication processes. Following a series of design stages teams submitted their proposals to be digitally fabricated using CNC knives, lasers and robotic arms. In the week of the festival teams then worked together to assemble and install their pre-fabricated pavilions, collectively creating the architecture for a large-scale public event. Building and celebration took place in Ambika P3 - a 14,000 square ft space in Central London developed from the University’s former concrete construction hall. The project ended in a three-day celebration with live music and making-based events for visitors and the local community

Learning Latent Factor Models of Travel Data for Travel Prediction and Analysis

Abstract. We describe latent factor probability models of human travel, which we learn from data. The latent factors represent interpretable properties: travel distance cost, desirability of destinations, and affinity between locations. Individuals are clustered into distinct styles of travel. The latent factors combine in a multiplicative manner, and are learned using Maximum Likelihood. We show that our models explain the data significantly better than histogrambased methods. We also visualize the model parameters to show information about travelers and travel patterns. We show that different individuals exhibit different propensity to travel large distances. We extract the desirability of destinations on the map, which is distinct from their popularity. We show that pairs of locations have different affinities with each other, and that these affinities are partly explained by travelers ’ preference for staying within national borders and within the borders of linguistic areas. The method is demonstrated on two sources of travel data: geotags from Flickr images, and GPS tracks from Shanghai taxis.

Особенности управления оборотными активами предприятия

Цель работы - изучение особенностей управления оборотными активами предприятия и рассмотрение различных подходов к управлению ими

Multifocal lymphadenopathies with polyclonal reactions primed after EBV infection in a mRNA-1273 vaccine recipient.

We report a case of recurrent tender, multifocal lymphadenopathies associated with B-symptoms, clinically mimicking lymphoma in a mRNA-1273 vaccine recipient after a recent Epstein-Barr virus (EBV) infection. In the lymph node biopsy, monocytoid B-cell hyperplasia, TH2 (GATA3+) predominance, and hyperplasia of interferon-gamma-producing plasmacytoid dendritic cells were observed along with sustained neutralising antibody production against SARS-CoV-2 wild-type and five variants. High titres of anti-S antibodies and neutralising antibodies were observed, excepted for variant B.1.529** (omicron) and B.1.351** (beta), due to several mutations in the spike protein, including the E484K mutation. We postulated that EBV acted as an immunological enhancer with the mRNA-1273 vaccine, inducing a sustained inflammatory response over several weeks. However, the polyclonal nature of the lymphadenopathy with polytypic plasmacytosis and pseudo-tumoural reaction cell hyperplasia were associated with failure to mount acute phase responses

Hepatitis C prevalences in the psychiatric setting: Cost-effectiveness of scaling-up screening and direct-acting antiviral therapy.

Patients hospitalised because of mental illness often have risk factors for contracting HCV. Scaling-up HCV screening for all psychiatric inpatients as a case-detection strategy for viral elimination is underexplored. This study aimed to evaluate the cost-effectiveness of scaling-up HCV screening and treatment for psychiatry hospital admissions in Switzerland vs. the current standard-of-care risk-based approach, where only those with a history of substance misuse disorder are offered testing. HCV prevalence by history of substance misuse disorder was analysed in medical records from inpatient admissions to a Swiss psychiatry department. Cost-effectiveness was analysed from a healthcare provider perspective through a decision-tree screening model, using these HCV prevalence data. Model and parameter uncertainty were assessed using deterministic and probabilistic sensitivity analyses. Prevalence of HCV in psychiatry inpatients with a history of substance misuse disorder (n = 1,013) was 25.7%, compared with 3.5% among the remaining inpatients (n = 3,535). Scaling up HCV screening and treatment for all psychiatry admissions was cost-effective vs. the risk-based approach, with an incremental cost-effectiveness ratio of US$9,188 per quality-adjusted life-year gained. The incremental cost-effectiveness ratio remained cost-effective considering a HCV prevalence as low as 0.07$435,156,348, with 917 additional patients per year detected and treated at a cost of US$3,294 per person (vs. US$2,122 under risk-based screening). Scaling up HCV screening and treatment at diagnosis with all-oral, interferon-free regimens as a generalised approach for psychiatric admissions was cost-effective and could support reaching World Health Organization targets for HCV elimination by 2030. Patients hospitalised because of mental illness often have risk factors for HCV. We found that testing all psychiatry patients in hospital for HCV was cost-effective compared with testing only patients who have a history of substance misuse. Scaling up HCV testing and treatment could help to wipe out HCV